Aziridine electrophiles in the functionalisation of peptide chains with amine nucleophiles.

Abstract

We describe herein the synthesis of aziridine-containing amino acids embedded within tripeptide structures. A range of amine nucleophiles have been shown to open the aziridine amino acid regioselectively at the β-position under mild conditions and without the requirement for a catalyst, forming new adducts in the process. Amino acid N-termini (or an N… (More)
DOI: 10.1039/c5ob00856e

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Cite this paper

@article{Spork2015AziridineEI, title={Aziridine electrophiles in the functionalisation of peptide chains with amine nucleophiles.}, author={Anatol P. Spork and Timothy J Donohoe}, journal={Organic & biomolecular chemistry}, year={2015}, volume={13 31}, pages={8545-9} }