Azidomorphines: a new family of potent analgesics with low dependence capacity.

@article{Knoll1979AzidomorphinesAN,
  title={Azidomorphines: a new family of potent analgesics with low dependence capacity.},
  author={J. Knoll},
  journal={Progress in neuro-psychopharmacology},
  year={1979},
  volume={3 1-3},
  pages={
          95-108
        }
}
  • J. Knoll
  • Published 1979
  • Medicine
  • Progress in neuro-psychopharmacology
  • 1. Structure-activity relationship studies with new semi-synthetic isomorphine derivatives revealed that substitution of an azido group in position 6 (azidomorphines) greatly increases the analgesic potency whereas tolerance and dependence liability tend to decrease. 2. Azidomorphine (6-deoxy-6-azidodihydroisomorphine) and 14-hydroxyazidomorphine (6-deoxy-6-azidodihydro-14-hydroxyisomorphine) being in animal tests 40-300 times more potent than morphine, are the most effective analgesics among… CONTINUE READING
    The medicinal chemistry of the azido group.
    • 54
    Azidomorphine is an agonist of high-affinity opioid receptor binding sites
    4,5-Epoxymorphinans
    • 2

    References

    Publications referenced by this paper.