Azido-containing aryl beta-diketo acid HIV-1 integrase inhibitors.


Aryl beta-diketo acids (ADK) comprise a general class of potent HIV-1 integrase (IN) inhibitors, which can exhibit selective inhibition of strand transfer reactions in extracellular recombinant IN assays and provide potent antiviral effects in HIV-infected cells. Recent studies have shown that polycyclic aryl or aryl rings bearing aryl-containing… (More)


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@article{Zhang2003AzidocontainingAB, title={Azido-containing aryl beta-diketo acid HIV-1 integrase inhibitors.}, author={Xuechun Zhang and Godwin C G Pais and Evguenia S Svarovskaia and Christophe H Marchand and Allison A. Johnson and Rajeshri G. Karki and Marc C. Nicklaus and Vinay K Pathak and Yves Pommier and Terrence R. Burke}, journal={Bioorganic & medicinal chemistry letters}, year={2003}, volume={13 6}, pages={1215-9} }