Azide Binding to the Diferrous Clusters of the R 2 Protein of Ribonucleotide Reductase from Escherichia coli

Abstract

Ribonucleotide reductases provide the only biosynthetic pathway for the generation of deoxyribonuc1eotides.l The Escherichia coli enzyme is a 1 : 1 complex of R1 and R2 proteins;2 the X-ray structure of the latter establishes the presence of two nonheme (p-oxo)diiron(III) clusters in close proximity to Tyr 122,3 which must be oxidized to its radical form to… (More)

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