Azelnidipine decreases sympathetic nerve activity via antioxidant effect in the rostral ventrolateral medulla of stroke-prone spontaneously hypertensive rats.

@article{Konno2008AzelnidipineDS,
  title={Azelnidipine decreases sympathetic nerve activity via antioxidant effect in the rostral ventrolateral medulla of stroke-prone spontaneously hypertensive rats.},
  author={Satomi Konno and Yoshitaka Hirooka and Shuichiro Araki and Yasuaki Koga and Takuya Kishi and Kenji Sunagawa},
  journal={Journal of cardiovascular pharmacology},
  year={2008},
  volume={52 6},
  pages={555-60}
}
The long-acting dihydropyridine calcium channel blocker, azelnidipine, is suggested to inhibit sympathetic nerve activity. We previously demonstrated that oxidative stress in the rostral ventrolateral medulla (RVLM) activates sympathetic nerve activity. The aim of the present study was to determine whether oral administration of azelnidipine inhibits sympathetic nerve activity and if so to determine whether the effect is mediated by antioxidant effect in the RVLM. Azelnidipine, hydralazine, or… CONTINUE READING
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ESH-ESC Task Force on the Management of Arterial Hypertension

  • G Mancia, G De Backer, A Dominiczak
  • J Hypertens
  • 2007
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Sympatho-inhibitory effects of azelnidipine in the patients with essential hypertension

  • T Kishi, Y. Hirooka
  • Ther Res
  • 2007

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