Azathioprine with prednisone for polymyositis. A controlled, clinical trial.

  title={Azathioprine with prednisone for polymyositis. A controlled, clinical trial.},
  author={Thomas W. Bunch and John W. Worthington and Julie P. Combs and Duane M. Ilstrup and Andrew G. Engel},
  journal={Annals of internal medicine},
  volume={92 3},
A controlled, prospective, double-blind, therapeutic trial of azathioprine was conducted in the initial therapy of polymyositis. Sixteen patients received 60 mg prednisone per day plus either azathioprine (2 mg/kg of body weight per day) or placebo for a period of 3 months. Creatine phosphokinase (CPK) levels fell to normal slightly sooner in the placebo group, but not significantly so. The azathioprine group did not become significantly stronger (P = 0.58) and did not manifest significantly… CONTINUE READING
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