Azathioprine/methylprednisolone versus cyclophosphamide in proliferative lupus nephritis. A randomized controlled trial.

@article{Grootscholten2006Azathioprinemethylprednisolo,
  title={Azathioprine/methylprednisolone versus cyclophosphamide in proliferative lupus nephritis. A randomized controlled trial.},
  author={Cecile Grootscholten and Gerry Ligtenberg and E. Christiaan Hagen and A Warmold L van den Wall Bake and J W de Glas-Vos and M. H. de Bijl and Karel J. M. Assmann and Jan Anthonie Bruijn and Jan J. Weening and Hans JC van Houwelingen and R. W. Derksen and J. H. M. Berden},
  journal={Kidney international},
  year={2006},
  volume={70 4},
  pages={732-42}
}
Until recently, intravenous cyclophosphamide pulses with oral corticosteroids were regarded standard therapy for proliferative lupus nephritis (LN). Azathioprine, a less toxic alternative, was never proven to be inferior. In the first Dutch lupus nephritis study (enrollment between 1995 and 2001), we randomized 87 proliferative LN patients to either cyclophosphamide pulses (750 mg/m(2), 13 pulses in 2 years) combined with oral prednisone (CY) or to azathioprine (2 mg/kg/day in 2 years) combined… CONTINUE READING