Azathioprine, mercaptopurine and birth outcome: a population‐based cohort study

@article{Nrgrd2003AzathioprineMA,
  title={Azathioprine, mercaptopurine and birth outcome: a population‐based cohort study},
  author={Bente Mertz N{\o}rg{\aa}rd and Lars Pedersen and Kirsten Fonager and S. N. Rasmussen and H. T. S{\o}rensen},
  journal={Alimentary Pharmacology \& Therapeutics},
  year={2003},
  volume={17}
}
Background : Data on the safety of azathioprine and mercaptopurine during pregnancy are very sparse. 
Birth outcome in women treated with azathioprine or mercaptopurine during pregnancy: a Danish nationwide cohort study
Data on birth outcome after exposure to azathioprine or mercaptopurine during pregnancy is sparse.
Systematic review with meta‐analysis: outcomes of pregnancy in patients with autoimmune hepatitis
Autoimmune hepatitis (AIH) is common in females of childbearing age. Although some studies have provided information about the outcomes of pregnancy, there remains uncertainty regarding conclusions.
Safety of azathioprine use during pregnancy.
TLDR
An increasing body of evidence from prospective cohort studies suggests that azathioprine is safe for the fetus during pregnancy, and many women are afraid to take a "cancer drug" during pregnancy.
The risk of chronic diseases and congenital malformations during childhood and adolescence after in utero exposure to thiopurines
Women with autoimmune diseases, particularly inflammatory bowel disease (IBD), often need to continue immunomodulatory therapies during pregnancy. While the evidence of birth and short‐term outcomes
Long‐term follow‐up of children exposed intrauterine to maternal thiopurine therapy during pregnancy in females with inflammatory bowel disease
Inflammatory bowel disease (IBD) affects a substantial number of female patients in their reproductive years. Therefore, many physicians face the dilemma whether thiopurines, prescribed to maintain
Prescribing of sulfasalazine, azathioprine and methotrexate round pregnancy—a descriptive study
TLDR
Prescription patterns round pregnancy of sulfasalazine, azathioprine, AZA, methotrexate and co‐medications among women to whom one of these DMARDs were prescribed before pregnancy are reported.
Pregnancy and inflammatory bowel disease.
  • U. Mahadevan
  • Medicine
    Gastroenterology clinics of North America
  • 2009
Pregnancy and inflammatory bowel disease.
  • U. Mahadevan
  • Medicine
    The Medical clinics of North America
  • 2010
Review article: reproduction in the patient with inflammatory bowel disease
TLDR
This clinical trial aimed at determining the effect of IBD and its treatment on fertility and pregnancy on a case-by-case basis on a outpatient basis.
Early pregnancy azathioprine use and pregnancy outcomes.
TLDR
Infants exposed to AZA in early pregnancy may be at a moderately increased risk of congenital malformations, specifically ventricular/atrial septal defects, and there is also an increasedrisk of growth restriction and preterm delivery.
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