Azathioprine, mercaptopurine and birth outcome: a population‐based cohort study
@article{Nrgrd2003AzathioprineMA, title={Azathioprine, mercaptopurine and birth outcome: a population‐based cohort study}, author={Bente Mertz N{\o}rg{\aa}rd and Lars Pedersen and Kirsten Fonager and S. N. Rasmussen and H. T. S{\o}rensen}, journal={Alimentary Pharmacology \& Therapeutics}, year={2003}, volume={17} }
Background : Data on the safety of azathioprine and mercaptopurine during pregnancy are very sparse.
145 Citations
Birth outcome in women treated with azathioprine or mercaptopurine during pregnancy: a Danish nationwide cohort study
- MedicineAlimentary pharmacology & therapeutics
- 2007
Data on birth outcome after exposure to azathioprine or mercaptopurine during pregnancy is sparse.
Systematic review with meta‐analysis: outcomes of pregnancy in patients with autoimmune hepatitis
- Medicine, BiologyAlimentary pharmacology & therapeutics
- 2022
Autoimmune hepatitis (AIH) is common in females of childbearing age. Although some studies have provided information about the outcomes of pregnancy, there remains uncertainty regarding conclusions.
Safety of azathioprine use during pregnancy.
- MedicineCanadian family physician Medecin de famille canadien
- 2011
An increasing body of evidence from prospective cohort studies suggests that azathioprine is safe for the fetus during pregnancy, and many women are afraid to take a "cancer drug" during pregnancy.
The risk of chronic diseases and congenital malformations during childhood and adolescence after in utero exposure to thiopurines
- Medicine, BiologyAlimentary pharmacology & therapeutics
- 2021
Women with autoimmune diseases, particularly inflammatory bowel disease (IBD), often need to continue immunomodulatory therapies during pregnancy. While the evidence of birth and short‐term outcomes…
Long‐term follow‐up of children exposed intrauterine to maternal thiopurine therapy during pregnancy in females with inflammatory bowel disease
- MedicineAlimentary pharmacology & therapeutics
- 2013
Inflammatory bowel disease (IBD) affects a substantial number of female patients in their reproductive years. Therefore, many physicians face the dilemma whether thiopurines, prescribed to maintain…
Prescribing of sulfasalazine, azathioprine and methotrexate round pregnancy—a descriptive study
- MedicinePharmacoepidemiology and drug safety
- 2008
Prescription patterns round pregnancy of sulfasalazine, azathioprine, AZA, methotrexate and co‐medications among women to whom one of these DMARDs were prescribed before pregnancy are reported.
Review article: reproduction in the patient with inflammatory bowel disease
- MedicineAlimentary pharmacology & therapeutics
- 2007
This clinical trial aimed at determining the effect of IBD and its treatment on fertility and pregnancy on a case-by-case basis on a outpatient basis.
Early pregnancy azathioprine use and pregnancy outcomes.
- MedicineBirth defects research. Part A, Clinical and molecular teratology
- 2009
Infants exposed to AZA in early pregnancy may be at a moderately increased risk of congenital malformations, specifically ventricular/atrial septal defects, and there is also an increasedrisk of growth restriction and preterm delivery.
References
SHOWING 1-10 OF 40 REFERENCES
Pregnancy after renal transplantation: 25 years experience in Spain
- Medicine, Political ScienceBritish journal of obstetrics and gynaecology
- 1993
The outcome of pregnancy in renal transplant patients in Spain is studied to study the impact of pregnancy on the outcome of treatment and quality of life in these patients.
Children of renal transplant recipient mothers
- MedicineJournal of paediatrics and child health
- 2000
Objective: To assess the current physical status and developmental outcome of children born to mothers following renal transplantation.
Azathioprine teratogenicity: review of the literature and case report.
- Medicine
- 1981
Experimental studies in animals reveal a teratogenic role for azathioprine and its main metabolite, 6-mercaptopurine, and the skeletal system appears to be the primary tissue target for action of these drugs.
Azathioprine teratogenicity: review of the literature and case report.
- MedicineObstetrics and gynecology
- 1981
Experimental studies in animals reveal a teratogenic role for azathioprine and its main metabolite, 6-mercaptopurine, and the skeletal system appears to be the primary tissue target for such action of these drugs.
Effects on the neonate of prednisone and azathioprine administered to the mother during pregnancy.
- Medicine, BiologyThe Journal of pediatrics
- 1974
Pregnancy outcome in renal allograft recipients: influence of ciclosporin A.
- MedicineEuropean journal of obstetrics, gynecology, and reproductive biology
- 1991
Azathioprine: an update on clinical efficacy and safety in inflammatory bowel disease.
- MedicineScandinavian journal of gastroenterology. Supplement
- 1999
AZA/6-MP therapy is efficacious in patients with active Crohn's disease, but the drug is especially valuable in the long-term treatment of patients with Crohn't disease and ulcerative colitis.
IOIBD questionnaire on the clinical use of azathioprine, 6‐mercaptopurine, cyclosporin A and methotrexate in the treatment of inflammatory bowel diseases
- MedicineEuropean journal of gastroenterology & hepatology
- 2000
Considerable experience exists in the use of immunosuppressive therapy in IBD; however, differential prescription behaviour exists between North America and Europe, and several significant differences were observed between the prescription behaviour of respondents working at university hospitals and non‐university hospitals, in relation to participation in clinical trials.
The treatment of inflammatory bowel disease with 6‐mercaptopurine or azathioprine
- MedicineAlimentary pharmacology & therapeutics
- 2001
Azathioprine and 6‐mercaptopurine have no place as monotherapy in the treatment of acute relapsing inflammatory bowel disease.