Azaphilones inhibit tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mice.

  title={Azaphilones inhibit tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mice.},
  author={Ken Yasukawa and Michiaki Takahashi and Shinsaku Natori and K Kawai and M Yamazaki and Mieko Takeuchi and Michio Takido},
  volume={51 1},
Monascorubrin (an azaphilone derivative) was isolated from Monascus anka, 'Monascus pigment', a natural pigment of food additivies, was extracted from Monasucs spp., and chaetoviridin A, one of the azaphilones, was isolated from Chaetomium globosum var. flavo-viridae. Application of 1 microgram of 12-O-tetradecanoylphorbol-13-acetate (TPA), a tumor promoting agent, to the mouse ear resulted in induction of inflammation. Among monascorubrin and related compounds assayed, monascorubrin… 
Limonoids and other secondary metabolites of Azadirachta indica (neem) and Azadirachta indica var. siamensis (Siamese neem), and their bioactivities
In this review chapter, isolation, characterization, and bioactivities, including melanogenesis-inhibitory activity, cancer chemopreventive property, cytotoxic activity, and antiinflammatory activity, of limonoids and other secondary metabolites of AI and AIS are presented.
Inhibitory effects of falconensins on 12-O-tetradecanoylphorbol-13-acetate-induced inflammatory ear edema in mice
It was demonstrated that azaphilonoid falconensins exert inhibitory effects against TPA-induced inflammation in the ears of mice to a comparable degree as moascorubrin and indomethacin, which are known to have antitumor-promoting and anti-inflammatory effects.
Structure-specific inhibition of cholesteryl ester transfer protein by azaphilones.
The relationship between the structures and their inhibitory activity indicated that the presence of an electrophilic ketone and/or enone at both C-6 and C-8 positions in the isochromane-like ring is essential for eliciting CETP inhibitory Activity.
Sch 1385568, a new azaphilone from Aspergillus sp.
The fermentation, isolation, structure elucidation and antimicrobial activity of a novel azaphilone Sch 1385568 from an Aspergillus sp.
Three new constituents from the fungus of Monascus purpureus and their anti-inflammatory activity
Abstract A chemical study on the EtOAc-soluble fraction of the 95% EtOH extract of red yeast rice fermented with the fungus Monascus purpureus BCRC 38110 (Eurotiaceae) has resulted in the isolation
Investigations into Chemical Components from Monascus purpureus with Photoprotective and Anti-Melanogenic Activities
Six new and two known compounds were isolated from M. purpureus, and two of them exhibited dermal protective activities, revealing the novel potential of M. Purpureus for developing natural cosmeceutics against skin photoaging.
Anti‐Tumor‐Initiating Effects of Monascin, an Azaphilonoid Pigment from the Extract of Monascus pilosus Fermented Rice (Red‐Mold Rice)
It is suggested that compound 1 may be valuable as potential cancer chemopreventive agent in chemical and environmental carcinogenesis.
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
The compounds suppressed cell proliferation and growth in five human cancer cell lines, but had no effect on the viability of normal human cell lines.
New brominated and halogen-less derivatives and structure-activity relationship of azaphilones inhibiting gp120-CD4 binding.
Nineteen azaphilone-related compounds isolated from the culture broth of a producing organism of isochromophilones I and II and from other fungi were tested for the inhibition of gp120-CD4 binding and the structure-activity relationship is discussed.
Penicillium verruculosum SG: a source of polyketide and bioactive compounds with varying cytotoxic activities against normal and cancer lines
These compounds considerably showed less toxicity toward normal cell lines NIH3T3, HSCT6, HEK293 and MDCK and showed significantly higher cytotoxic activities against normal and cancer cell lines.