Azaphilones inhibit tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mice.

  title={Azaphilones inhibit tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mice.},
  author={Ken Yasukawa and M. Takahashi and Shinsaku Natori and K Kawai and M Yamazaki and Mieko Takeuchi and Michio Takido},
  volume={51 1},
Monascorubrin (an azaphilone derivative) was isolated from Monascus anka, 'Monascus pigment', a natural pigment of food additivies, was extracted from Monasucs spp., and chaetoviridin A, one of the azaphilones, was isolated from Chaetomium globosum var. flavo-viridae. Application of 1 microgram of 12-O-tetradecanoylphorbol-13-acetate (TPA), a tumor promoting agent, to the mouse ear resulted in induction of inflammation. Among monascorubrin and related compounds assayed, monascorubrin… 

Inhibitory effects of falconensins on 12-O-tetradecanoylphorbol-13-acetate-induced inflammatory ear edema in mice

It was demonstrated that azaphilonoid falconensins exert inhibitory effects against TPA-induced inflammation in the ears of mice to a comparable degree as moascorubrin and indomethacin, which are known to have antitumor-promoting and anti-inflammatory effects.

Structure-specific inhibition of cholesteryl ester transfer protein by azaphilones.

The relationship between the structures and their inhibitory activity indicated that the presence of an electrophilic ketone and/or enone at both C-6 and C-8 positions in the isochromane-like ring is essential for eliciting CETP inhibitory Activity.

Sch 1385568, a new azaphilone from Aspergillus sp.

The fermentation, isolation, structure elucidation and antimicrobial activity of a novel azaphilone Sch 1385568 from an Aspergillus sp.

Anti‐Tumor‐Initiating Effects of Monascin, an Azaphilonoid Pigment from the Extract of Monascus pilosus Fermented Rice (Red‐Mold Rice)

It is suggested that compound 1 may be valuable as potential cancer chemopreventive agent in chemical and environmental carcinogenesis.

Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.

The compounds suppressed cell proliferation and growth in five human cancer cell lines, but had no effect on the viability of normal human cell lines.

New brominated and halogen-less derivatives and structure-activity relationship of azaphilones inhibiting gp120-CD4 binding.

Nineteen azaphilone-related compounds isolated from the culture broth of a producing organism of isochromophilones I and II and from other fungi were tested for the inhibition of gp120-CD4 binding and the structure-activity relationship is discussed.

Progress toward the asymmetric total synthesis of chaetoglobin a selective oxidative homo- and cross-coupling of phenols using aerobic catalysts

The chaetoglobins are a structurally unique class of azaphilone alkaloid dimers with reported anticancer activity. They are also a potential platform for the development of antibacterial and

Anti-inflammatory properties of yellow and orange pigments from Monascus purpureus NTU 568.

Six azaphilonoid pigments, namely, ankaflavin, monaphilone A, and monaphils A-D, showed high potential to be developed into chemopreventive foods or drugs against inflammation-associated diseases.