Azaphilones inhibit tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mice.

@article{Yasukawa1994AzaphilonesIT,
  title={Azaphilones inhibit tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mice.},
  author={Ken Yasukawa and Michiaki Takahashi and Shinsaku Natori and K Kawai and M Yamazaki and Mieko Takeuchi and Michio Takido},
  journal={Oncology},
  year={1994},
  volume={51 1},
  pages={
          108-12
        }
}
Monascorubrin (an azaphilone derivative) was isolated from Monascus anka, 'Monascus pigment', a natural pigment of food additivies, was extracted from Monasucs spp., and chaetoviridin A, one of the azaphilones, was isolated from Chaetomium globosum var. flavo-viridae. Application of 1 microgram of 12-O-tetradecanoylphorbol-13-acetate (TPA), a tumor promoting agent, to the mouse ear resulted in induction of inflammation. Among monascorubrin and related compounds assayed, monascorubrin… 
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