Azagrevellins, Part I. Grevellin analogs with affinity to the N-methyl-D-aspartate (glycine site) receptor, a novel lead structure.

Abstract

A series of piperidine-2,3,5-triones (azagrevellins) has been prepared. A new synthesis has been introduced using the rearrangement of spiroepoxides in the presence of triethyloxonium tetrafluoroborate. The binding affinity toward the N-methyl-D-aspartate (glycine site) receptor has been measured to provide a basis for more detailed structure-activity studies. Azagrevellin 18d showed the highest binding potency.

Cite this paper

@article{Poschenrieder2000AzagrevellinsPI, title={Azagrevellins, Part I. Grevellin analogs with affinity to the N-methyl-D-aspartate (glycine site) receptor, a novel lead structure.}, author={Hermann Poschenrieder and Georg C Hoefner and H D Stachel}, journal={Archiv der Pharmazie}, year={2000}, volume={333 7}, pages={211-6} }