Azacytidine-induced reactivation of a DNA repair gene in Chinese hamster ovary cells.

@article{Jeggo1986AzacytidineinducedRO,
  title={Azacytidine-induced reactivation of a DNA repair gene in Chinese hamster ovary cells.},
  author={Penny A Jeggo and Robin Holliday},
  journal={Molecular and cellular biology},
  year={1986},
  volume={6 8},
  pages={2944-9}
}
Six X-ray-sensitive (xrs) strains of the CHO-K1 cell line were shown to revert at a very high frequency after treatment with 5-azacytidine. This suggested that there was a methylated xrs+ gene in these strains which was structurally intact, but not expressed. The xrs strains did not complement one another, and the locus was autosomally located. In view of the frequency of their isolation and their somewhat different phenotypes, we propose that the xrs strains are mutants derived from an active… CONTINUE READING

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