Azaanalogues of ebselen as antimicrobial and antiviral agents: synthesis and properties.

@article{Wjtowicz2004AzaanaloguesOE,
  title={Azaanalogues of ebselen as antimicrobial and antiviral agents: synthesis and properties.},
  author={Halina W{\'o}jtowicz and Krzysztof Kloc and Irena Maliszewska and Jacek Młochowski and Małgorzata Pietka and Egbert Piasecki},
  journal={Farmaco},
  year={2004},
  volume={59 11},
  pages={863-8}
}
The different analogues of ebselen-unsubstituted benzisoselenazol-3(2H)-one (2a) 2-pyridylbenzisoselenazol-3(2H)-ones (2b-h) and 7-azabenzisoselenazol-3(2H)-ones (3a-j) were designed as new selenium-containing antiviral and antimicrobial agents and synthesized. Some of them were found in the antiviral assay in vitro to be strong inhibitors of cythopatic activity of herpes simplex virus type 1--HSV-1 (compounds 2a,b,f,h, 3a-j) and encephalomyocarditis virus--EMCV (compounds 2a,h, 3a-f,k,l). The… CONTINUE READING

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