Aza-Henry Reactions on C-Alkyl Substituted Aldimines.

Abstract

The reactivity of C-CH₃ substituted N-protected aldimines in aza-Henry addition reactions was compared with that of the analogous trifluoromethylated compounds. C-Alkyl aldimines easily reacted with nitro alkanes under solvent-free conditions and in the absence of catalyst, despite being worse electrophiles than C-CF₃ aldimines, they gave the aza-Henry addition only when ZrCl₄ was added. The presence of a bulky group on the imine carbon deeply influenced the reactivity.

DOI: 10.3390/molecules21060723

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Cite this paper

@article{Pelagalli2016AzaHenryRO, title={Aza-Henry Reactions on C-Alkyl Substituted Aldimines.}, author={Alessia Pelagalli and Lucio Pellacani and Elia Scandozza and S. Fioravanti}, journal={Molecules}, year={2016}, volume={21 6} }