Axotomy induces nerve growth factor receptor immunoreactivity in spinal motor neurons

@article{Koliatsos1991AxotomyIN,
  title={Axotomy induces nerve growth factor receptor immunoreactivity in spinal motor neurons},
  author={Vassilis E. Koliatsos and Thomas O. Crawford and Donald L. Price},
  journal={Brain Research},
  year={1991},
  volume={549},
  pages={297-304}
}
Expression of the nerve growth factor receptor (NGF-R) mRNA in adult motor neurons is increased by axonal injury. The present study was designed to examine, by immunocytochemistry, the onset, course, and specificity of NGF-R up-regulation following distal or proximal crush of the sciatic nerve. Lesions at both levels induced the appearance of NGF-R-like immunoreactivity in motor neurons beginning on day two postaxotomy. NGF-R-like immunoreactivity was present exclusively in axotomized neurons… CONTINUE READING

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