Axotomy-induced c-JUN expression in young medial septal neurons is regulated by nerve growth factor.

@article{Haas1998AxotomyinducedCE,
  title={Axotomy-induced c-JUN expression in young medial septal neurons is regulated by nerve growth factor.},
  author={Carola A Haas and Alfred Bach and Bernd Heimrich and Rudiger Linke and Uwe Otten and Michael Frotscher},
  journal={Neuroscience},
  year={1998},
  volume={87 4},
  pages={831-44}
}
In the present study we investigated the axotomy-induced expression of the proto-oncogene c-jun in young rat medial septal neurons and its regulation by nerve growth factor. First, medial septal neurons were retrogradely labelled by Fast Blue injection into the hippocampus at postnatal day 1 (P1). Rats of different developmental ages (P6, P9, P14, P21, P28 and P42) were then subjected to bilateral fimbria-fornix transection resulting in the axotomy of septohippocampal projection neurons. After… CONTINUE READING