Axonal transport of activating transcription factor-2 is modulated by nerve growth factor in nociceptive neurons.

@article{Delcroix1999AxonalTO,
  title={Axonal transport of activating transcription factor-2 is modulated by nerve growth factor in nociceptive neurons.},
  author={J D Delcroix and Sharon A Averill and Karla C Fernandes and David Richard Tomlinson and John V. Priestley and Paul Fernyhough},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1999},
  volume={19 18},
  pages={RC24}
}
The aim of this study was to determine whether axonal transport of activating transcription factor-2 (ATF2) occurs in adult sensory neurons, and whether this process is under neurotrophin control. Antisera to both total ATF2 and to the activated (i.e., phosphorylated) form were used for immunocytochemistry and Western blotting. ATF2 was localized to predominantly nociceptive dorsal root ganglion cells in adult rats and shown to accumulate proximal and distal to a sciatic nerve ligature as a… CONTINUE READING