Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited.

@article{Lazarov2005AxonalTA,
  title={Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited.},
  author={Orly Lazarov and Gerardo A Morfini and Edward K. B. Lee and Mohamed Farah and Anita Szodorai and Scott R DeBoer and Vassilis E. Koliatsos and Stefan Kins and Virginia M-Y Lee and Philip Chuen Yung Wong and Donald L. Price and Scott T Brady and Sangram S. Sisodia},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2005},
  volume={25 9},
  pages={2386-95}
}
The sequential enzymatic actions of beta-APP cleaving enzyme 1 (BACE1), presenilins (PS), and other proteins of the gamma-secretase complex liberate beta-amyloid (Abeta) peptides from larger integral membrane proteins, termed beta-amyloid precursor proteins (APPs). Relatively little is known about the normal function(s) of APP or the neuronal compartment(s) in which APP undergoes proteolytic processing. Recent studies have been interpreted as consistent with the idea that APP serves as a… CONTINUE READING

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