Axonal transection in the lesions of multiple sclerosis.

  title={Axonal transection in the lesions of multiple sclerosis.},
  author={Bruce D. Trapp and John W. Peterson and Richard M. Ransohoff and Richard A. Rudick and Sverre J. M{\"o}rk and Lars B{\"o}},
  journal={The New England journal of medicine},
  volume={338 5},
  • B. Trapp, J. Peterson, L. Bö
  • Published 29 January 1998
  • Medicine, Biology, Psychology
  • The New England journal of medicine
BACKGROUND Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system and is the most common cause of neurologic disability in young adults. Despite antiinflammatory or immunosuppressive therapy, most patients have progressive neurologic deterioration that may reflect axonal loss. We conducted pathological studies of brain tissues to define the changes in axons in patients with multiple sclerosis. METHODS Brain tissue was obtained at autopsy from 11 patients… 

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