Axonal stress kinase activation and tau misbehavior induced by kinesin-1 transport defects.

@article{Falzone2009AxonalSK,
  title={Axonal stress kinase activation and tau misbehavior induced by kinesin-1 transport defects.},
  author={Tom{\'a}s Luis Falzone and Gorazd B Stokin and Concepci{\'o}n Lillo and Elizabeth M. Rodrigues and Eileen L Westerman and David S Williams and Lawrence S. B. Goldstein},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2009},
  volume={29 18},
  pages={5758-67}
}
Many neurodegenerative diseases exhibit axonal pathology, transport defects, and aberrant phosphorylation and aggregation of the microtubule binding protein tau. While mutant tau protein in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP17) causes aberrant microtubule binding and assembly of tau into filaments, the pathways leading to tau-mediated neurotoxicity in Alzheimer's disease and other neurodegenerative disorders in which tau protein is not genetically modified… CONTINUE READING
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