Axonal protection by brimonidine with modulation of p62 expression in TNF-induced optic nerve degeneration

Abstract

The p62, also called sequestosome 1 (SQSTM1), plays a crucial role in tumor necrosis factor (TNF)-induced optic nerve degeneration. Brimonidine has been shown to have protective effects on retinal ganglion cell bodies, although its role in their axons remains to be examined. We determined whether brimonidine modulates axonal loss induced by TNF and affects… (More)
DOI: 10.1007/s00417-015-3005-3

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