Axonal pathology in myelin disorders.

  title={Axonal pathology in myelin disorders.},
  author={Carl Bjartmar and Xinghua Yin and Bruce D Trapp},
  journal={Journal of neurocytology},
  volume={28 4-5},
Myelination provides extrinsic trophic signals that influence normal maturation and long-term survival of axons. The extent of axonal involvement in diseases affecting myelin or myelin forming cells has traditionally been underestimated. There are, however, many examples of axon damage as a consequence of dysmyelinating or demyelinating disorders. More than a century ago, Charcot described the pathology of multiple sclerosis (MS) in terms of demyelination and relative sparing of axons. Recent… CONTINUE READING
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