Axonal neuropathy in a patient with IgM M-protein reactive with nerve endoneurium.

@article{Freddo1985AxonalNI,
  title={Axonal neuropathy in a patient with IgM M-protein reactive with nerve endoneurium.},
  author={Lorenza Freddo and Arthur P. Hays and William H. Sherman and Norman Latov},
  journal={Neurology},
  year={1985},
  volume={35 9},
  pages={1321-5}
}
IgM M-proteins have been found in patients with axonal neuropathies, but it is not known whether these M-proteins bind to nerve components or actually cause the neuropathy. In one patient with axonal neuropathy studied, the IgM M-protein bound to chondroitin sulfate, and there were deposits of IgM in the endoneurium of the patient's nerve. A monoclonal anti-idiotype antibody generated against that M-protein was used to study the binding of the M-protein to normal nerve and to distinguish it… CONTINUE READING

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