Axonal neurofilaments control multiple fiber properties but do not influence structure or spacing of nodes of Ranvier.

@article{Perrot2007AxonalNC,
  title={Axonal neurofilaments control multiple fiber properties but do not influence structure or spacing of nodes of Ranvier.},
  author={Rodolphe Perrot and Pierre Lonchampt and Alan C. Peterson and Jo{\"e}l Eyer},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2007},
  volume={27 36},
  pages={9573-84}
}
In the vertebrate nervous system, axon calibers correlate positively with myelin sheath dimensions and electrophysiological parameters including action potential amplitude and conduction velocity. Neurofilaments, a prominent component of the neuronal cytoskeleton, are required by axons to support their normal radial growth. To distinguish between fiber features that arise in response to absolute axon caliber and those that are under autonomous control, we investigated transgenic mice in which… CONTINUE READING