Axonal loss and neurofilament phosphorylation changes accompany lesion development and clinical progression in multiple sclerosis.

@article{Schirmer2011AxonalLA,
  title={Axonal loss and neurofilament phosphorylation changes accompany lesion development and clinical progression in multiple sclerosis.},
  author={Lucas Vin{\'i}cius Schirmer and Jack P. Antel and Wolfgang Br{\"u}ck and Christine Stadelmann},
  journal={Brain pathology},
  year={2011},
  volume={21 4},
  pages={
          428-40
        }
}
Neuroaxonal damage and loss are increasingly recognized as disability determining features in multiple sclerosis (MS) pathology. However, little is known about the long-term sequelae of inflammatory demyelination on neurons and axons. Spinal cord tissue of 31 MS patients was compared to three amyotrophic lateral sclerosis (ALS) and 10 control subjects. MS lesions were staged according to the density of KiM-1P positive macrophages and microglia and the presence of myelin basic protein (MBP… CONTINUE READING
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