Axonal guidance protein FEZ1 associates with tubulin and kinesin motor protein to transport mitochondria in neurites of NGF-stimulated PC12 cells.

@article{Fujita2007AxonalGP,
  title={Axonal guidance protein FEZ1 associates with tubulin and kinesin motor protein to transport mitochondria in neurites of NGF-stimulated PC12 cells.},
  author={Toshitsugu Fujita and Andr{\'e}s Daniel Maturana and Junko Ikuta and Juri Hamada and Sebastien Walchli and Tadaki Suzuki and H Sawa and Michael Wooten and Toshihide Okajima and Kenji Tatematsu and Katsuyuki Tanizawa and Shun'ichi Kuroda},
  journal={Biochemical and biophysical research communications},
  year={2007},
  volume={361 3},
  pages={605-10}
}
Fasciculation and elongation protein zeta-1 (FEZ1) promotes efficiently the neurite elongation of rat phaeochromocytoma PC12 cells. We here characterized FEZ1 in PC12 cells. Nerve growth factor (NGF) stimulation induces significant expression of endogenous FEZ1 in PC12 cells. Upon NGF stimulation FEZ1 localizes in both cytoplasm and neuritis, co-localizing with mitochondria. Silencing of FEZ1 by RNA interference efficiently reduces NGF-induced neurite elongation and the anterograde motility of… CONTINUE READING

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