Axonal flip-flops and oscillators.


The strange and unpleasant sensations (paraesthesiae) or asynchronous motor-unit activation (fasciculation) that result from a period of limb ischaemia are examples of ectopic discharge in peripheral nerves. Ectopic activity also results from demyelination and is associated with serious neurological conditions, such as multiple sclerosis. A build-up of extracellular K(+) in the internode and persistent Na(+) currents are now implicated in generating the different forms of activity arising in normal and demyelinated axons.

Cite this paper

@article{Baker2000AxonalFA, title={Axonal flip-flops and oscillators.}, author={Mark D Baker}, journal={Trends in neurosciences}, year={2000}, volume={23 11}, pages={514-9} }