Axonal degeneration in motor neuron disease.

  title={Axonal degeneration in motor neuron disease.},
  author={Lindsey R. Fischer and Jonathan D. Glass},
  journal={Neuro-degenerative diseases},
  volume={4 6},
Growing evidence from animal models and patients with amyotrophic lateral sclerosis (ALS) suggests that distal axonal degeneration begins very early in this disease, long before symptom onset and motor neuron death. The cause of axonal degeneration is unknown, and may involve local axonal damage, withdrawal of trophic support from a diseased cell body, or both. It is increasingly clear that axons are not passive extensions of their parent cell bodies, and may die by mechanisms independent of… CONTINUE READING