Axonal damage induced by invading T cells in organotypic central nervous system tissue in vitro: involvement of microglial cells.

@article{Gimsa2000AxonalDI,
  title={Axonal damage induced by invading T cells in organotypic central nervous system tissue in vitro: involvement of microglial cells.},
  author={Ulrike Gimsa and Sebastian Peter and Kathrin Lehmann and Ingo Bechmann and Roger Nitsch},
  journal={Brain pathology},
  year={2000},
  volume={10 3},
  pages={
          365-77
        }
}
Neuroinflammation in the course of multiple sclerosis and experimental autoimmune encephalomyelitis results in demyelination and, recently demonstrated, axonal loss. Invading neuroantigen specific T cells are the crucial cellular elements in these processes. Here we demonstrate that invasion of activated T cells induces a massive microglial attack on myelinated axons in entorhinal-hippocampal slice cultures. Flow cytometry analysis of activation markers revealed that the activation state of… CONTINUE READING

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