Axonal damage in acute multiple sclerosis lesions.

@article{Ferguson1997AxonalDI,
  title={Axonal damage in acute multiple sclerosis lesions.},
  author={B. Ferguson and Malgosia K. Matyszak and Margaret M. Esiri and V Hugh Perry},
  journal={Brain : a journal of neurology},
  year={1997},
  volume={120 ( Pt 3)},
  pages={
          393-9
        }
}
One of the histological hallmarks of early multiple sclerosis lesions is primary demyelination, with myelin destruction and relative sparing of axons. On the other hand, it is widely accepted that axonal loss occurs in, and is responsible for, the permanent disability characterizing the later chronic progressive stage of the disease. In this study, we have used an antibody against amyloid precursor protein, known to be a sensitive marker of axonal damage in a number of other contexts, in… 

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