Axonal damage accumulates in the progressive phase of multiple sclerosis: three year follow up study.

@article{Petzold2005AxonalDA,
  title={Axonal damage accumulates in the progressive phase of multiple sclerosis: three year follow up study.},
  author={Axel Petzold and M. Judith Eikelenboom and Geoffrey Keir and Donna Grant and Richard H C Lazeron and Chris H. Polman and Bernard M. J. Uitdehaag and Edward J. Thompson and Gavin Giovannoni},
  journal={Journal of neurology, neurosurgery, and psychiatry},
  year={2005},
  volume={76 2},
  pages={206-11}
}
BACKGROUND Neurofilament phosphoforms (Nf) are principal components of the axoskeleton released during axonal injury. Cerebrospinal fluid (CSF) levels of Nf phosphoforms might be useful surrogate markers for disability in multiple sclerosis (MS), aid in distinguishing clinical subtypes, and provide valuable prognostic information. METHOD Thirty four patients with MS were included in a three year follow up study along with 318 controls with other non-inflammatory neurological diseases. CSF… CONTINUE READING
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