Axonal channelopathies: an evolving concept in the pathogenesis of peripheral nerve disorders.

Abstract

Abnormalities of peripheral nerve Na+ and K+ channels result in clinical manifestations unrelated to axonal degeneration or demyelination. Na+ channel blockade causes weakness and sensory loss associated with slowed conduction and decreased motor and sensory action potential amplitudes. K+ channel abnormalities result in high frequency repetitive action potentials (e.g., myokymia). Ion channel abnormalities may also play an important role in electrophysiologic changes seen in demyelinating disorders.

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@article{Gutmann1996AxonalCA, title={Axonal channelopathies: an evolving concept in the pathogenesis of peripheral nerve disorders.}, author={Ludwig Gutmann}, journal={Neurology}, year={1996}, volume={47 1}, pages={18-21} }