Axonal channelopathies: an evolving concept in the pathogenesis of peripheral nerve disorders.

@article{Gutmann1996AxonalCA,
  title={Axonal channelopathies: an evolving concept in the pathogenesis of peripheral nerve disorders.},
  author={Laurie Gutmann},
  journal={Neurology},
  year={1996},
  volume={47 1},
  pages={18-21}
}
Abnormalities of peripheral nerve Na+ and K+ channels result in clinical manifestations unrelated to axonal degeneration or demyelination. Na+ channel blockade causes weakness and sensory loss associated with slowed conduction and decreased motor and sensory action potential amplitudes. K+ channel abnormalities result in high frequency repetitive action potentials (e.g., myokymia). Ion channel abnormalities may also play an important role in electrophysiologic changes seen in demyelinating… CONTINUE READING
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