Axonal autophagosomes recruit dynein for retrograde transport through fusion with late endosomes

@inproceedings{Cheng2015AxonalAR,
  title={Axonal autophagosomes recruit dynein for retrograde transport through fusion with late endosomes},
  author={Xiu-Tang Cheng and Bing Zhou and M T Lin and Qian Cai and Zu-Hang Sheng},
  booktitle={The Journal of cell biology},
  year={2015}
}
Efficient degradation of autophagic vacuoles (AVs) via lysosomes is an important cellular homeostatic process. This is particularly challenging for neurons because mature acidic lysosomes are relatively enriched in the soma. Although dynein-driven retrograde transport of AVs was suggested, a fundamental question remains how autophagosomes generated at distal axons acquire dynein motors for retrograde transport toward the soma. In this paper, we demonstrate that late endosome (LE)-loaded dynein… CONTINUE READING
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386 required for efficient initiation of retrograde axonal transport

R. A. Nixon
J . Neurosci . • 2015

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