Axonal and neuromuscular synaptic phenotypes in Wld(S), SOD1(G93A) and ostes mutant mice identified by fiber-optic confocal microendoscopy.

@article{Wong2009AxonalAN,
  title={Axonal and neuromuscular synaptic phenotypes in Wld(S), SOD1(G93A) and ostes mutant mice identified by fiber-optic confocal microendoscopy.},
  author={Frances Wong and Li Fan and Sara Wells and Robert Hartley and Francesca E. Mackenzie and Oyinlola Oyebode and Rosalind Brown and Derek Thomson and Michael P. Coleman and Gonzalo Blanco and Richard R Ribchester},
  journal={Molecular and cellular neurosciences},
  year={2009},
  volume={42 4},
  pages={296-307}
}
We used live imaging by fiber-optic confocal microendoscopy (CME) of yellow fluorescent protein (YFP) expression in motor neurons to observe and monitor axonal and neuromuscular synaptic phenotypes in mutant mice. First, we visualized slow degeneration of axons and motor nerve terminals at neuromuscular junctions following sciatic nerve injury in Wld(S) mice with slow Wallerian degeneration. Protection of axotomized motor nerve terminals was much weaker in Wld(S) heterozygotes than in… CONTINUE READING