Axonal activation-induced calcium transients in myelinating Schwann cells, sources, and mechanisms.

@article{LevRam1995AxonalAC,
  title={Axonal activation-induced calcium transients in myelinating Schwann cells, sources, and mechanisms.},
  author={Varda Lev-Ram and Mark H. Ellisman},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1995},
  volume={15 4},
  pages={2628-37}
}
We have investigated the role of myelinating glia in events associated with propagation of the action potential at nodes of Ranvier using combinations of optical and electrophysiological recording methods. Calcium transients were observed in Schwann cells by fluorescent imaging of the nodal complex of fibers loaded with the calcium-sensitive dye fluo3-AM. To follow [Ca2+]i changes associated with neuronal activity at the node of Ranvier, nerves loaded with fluo3 were imaged during axonal… CONTINUE READING

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