Axonal Transport Impairment in Chemotherapy-Induced Peripheral Neuropathy

  title={Axonal Transport Impairment in Chemotherapy-Induced Peripheral Neuropathy},
  author={Gabriella Nicolini and Marianna Monfrini and Arianna Scuteri},
Chemotherapy-Induced Peripheral Neuropathy (CIPN) is a dose-limiting side effect of several antineoplastic drugs which significantly reduces patients' quality of life. Although different molecular mechanisms have been investigated, CIPN pathobiology has not been clarified yet. It has largely been recognized that Dorsal Root Ganglia are the main targets of chemotherapy and that the longest nerves are the most damaged, together with fast axonal transport. Indeed, this bidirectional cargo-specific… CONTINUE READING
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