Axonal Protein Synthesis Provides a Mechanism for Localized Regulation at an Intermediate Target

@article{Brittis2002AxonalPS,
  title={Axonal Protein Synthesis Provides a Mechanism for Localized Regulation at an Intermediate Target},
  author={Perry A. Brittis and Qiang Lu and John G. Flanagan},
  journal={Cell},
  year={2002},
  volume={110},
  pages={223-235}
}
As axons grow past intermediate targets, they change their responsiveness to guidance cues. Local upregulation of receptor expression is involved, but the mechanisms for this are not clear. Here protein synthesis is traced within individual axons by introducing RNAs encoding visualizable reporters. Individual severed axons and growth cones can translate proteins and also export them to the cell surface. As axons reach the spinal cord midline, EphA2 is among the receptors upregulated on at least… CONTINUE READING
Highly Influential
This paper has highly influenced 18 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 186 extracted citations

RNA-based mechanisms underlying axon guidance

The Journal of cell biology • 2013
View 5 Excerpts
Highly Influenced

How does an axon grow?

Genes & development • 2003
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 52 references

Cytoplasmic polyadenylation in development and beyond.

Microbiology and molecular biology reviews : MMBR • 1999
View 7 Excerpts
Highly Influenced

B61, a ligand for the Eck receptor proteinBrose, K., and Tessier-Lavigne, M

E. B. Pasquale
central nervous system. Exp. Neurol • 1996
View 4 Excerpts
Highly Influenced

Protein synthesis

J. Alvarez, A. Giuditta, E. Koenig
2000
View 5 Excerpts
Highly Influenced

Chemotropic responses of thesis and its role in synapse - specific plasticity

K. C. Martin, M. Barad, E. R. Kandel, D. S. Campbell, C. E. Holt
Curr . Opin . Neuro - retinal growth cones mediated by rapid local protein synthesis and biol . • 2001

Ephrin - cell adhesion molecule perturbations — a time - lapse study of the B reverse signaling is mediated by a novel PDZ - RGS protein andliving retina

Q. Lu, E. E. Sun, R. S. Klein, J. G. Flanagan
Mol . Cell . Neurosci . • 2001
View 1 Excerpt

Similar Papers

Loading similar papers…