Axonal Neuregulin-1 Regulates Myelin Sheath Thickness

@article{Michailov2004AxonalNR,
  title={Axonal Neuregulin-1 Regulates Myelin Sheath Thickness},
  author={G. V. Michailov and Michael W Sereda and Bastian G Brinkmann and Tobias M. Fischer and Bernhard Haug and Carmen Birchmeier and Lorna W. Role and Cary Lai and Markus H. Schwab and Klaus-Armin Nave},
  journal={Science},
  year={2004},
  volume={304},
  pages={700 - 703}
}
In the nervous system of vertebrates, myelination is essential for rapid and accurate impulse conduction. Myelin thickness depends on axon fiber size. We use mutant and transgenic mouse lines to show that axonal Neuregulin-1 (Nrg1) signals information about axon size to Schwann cells. Reduced Nrg1 expression causes hypomyelination and reduced nerve conduction velocity. Neuronal overexpression of Nrg1 induces hypermyelination and demonstrates that Nrg1 type III is the responsible isoform. We… 
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TLDR
It is demonstrated that the modulation of axon-to-glial NRG1 type III signaling has beneficial effects and improves myelination defects during development in a model of CHN.
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TLDR
Results suggest that disruption of the NRG1–erbB signaling pathway could contribute to the pathogenesis of peripheral neuropathies with hypomyelination and neuropathic pain.
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  • Biology
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  • 2012
TLDR
The current understanding of the axonal signals that drive Schwann cells towards these distinct morphological and phenotypic fates is reviewed, which may lead to new, rational therapies for the treatment of inherited and acquired neuropathies.
Schwann cell myelination.
  • J. Salzer
  • Biology
    Cold Spring Harbor perspectives in biology
  • 2015
TLDR
Current understanding of the development, molecular organization, and function of the myelinating Schwann cells is reviewed and recent findings into the extrinsic signals that drive Schwann cell myelination, their cognate receptors, and the downstream intracellular signaling pathways they activate are described.
Neuregulin 1 type III reduces severity in a mouse model of Congenital Hypomyelinating Neuropathy
TLDR
It is demonstrated that the modulation of axon-to-glial neuregulin 1 type III signaling has beneficial effects and restores myelination defects during development in a model of CHN.
Type III neuregulin‐1 promotes oligodendrocyte myelination
TLDR
It is indicated that oligodendrocyte myelination, but not differentiation, is promoted by axonal NRG1, underscoring important differences in the control of myelinations in the CNS and peripheral nervous system (PNS).
Neuregulin‐1, a key axonal signal that drives Schwann cell growth and differentiation
TLDR
An extensive line of research has revealed that one neuronal factor, termed “neuregulin”, promotes Schwann cell growth and survival, migration along the extending axon, and myelination, and the versatility of glial responses elicited by this factor is clearly astounding.
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