Axonal Motility and Its Modulation by Activity Are Branch-Type Specific in the Intact Adult Cerebellum

@article{Nishiyama2007AxonalMA,
  title={Axonal Motility and Its Modulation by Activity Are Branch-Type Specific in the Intact Adult Cerebellum},
  author={Hiroshi Nishiyama and Masahiro Fukaya and Masahiko Watanabe and David E. J. Linden},
  journal={Neuron},
  year={2007},
  volume={56},
  pages={472-487}
}
We performed two-photon in vivo imaging of cerebellar climbing fibers (CFs; the terminal arbor of olivocerebellar axons) in adult mice. CF ascending branches innervate Purkinje cells while CF transverse branches show a near complete failure to form conventional synapses. Time-lapse imaging over hours or days revealed that ascending branches were very stable. However, transverse branches were highly dynamic, exhibiting rapid elongation and retraction and varicosity turnover. Thus, different… CONTINUE READING