Axonal Degeneration in Tauopathies: Disease Relevance and Underlying Mechanisms

@inproceedings{Kneynsberg2017AxonalDI,
  title={Axonal Degeneration in Tauopathies: Disease Relevance and Underlying Mechanisms},
  author={Andrew Kneynsberg and Benjamin Combs and Kyle Christensen and Gerardo Morfini and Nicholas M Kanaan},
  booktitle={Front. Neurosci.},
  year={2017}
}
Tauopathies are a diverse group of diseases featuring progressive dying-back neurodegeneration of specific neuronal populations in association with accumulation of abnormal forms of the microtubule-associated protein tau. It is well-established that the clinical symptoms characteristic of tauopathies correlate with deficits in synaptic function and neuritic connectivity early in the course of disease, but mechanisms underlying these critical pathogenic events are not fully understood… CONTINUE READING
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