Axon tracts guide zebrafish facial branchiomotor neuron migration through the hindbrain.

@article{Wanner2013AxonTG,
  title={Axon tracts guide zebrafish facial branchiomotor neuron migration through the hindbrain.},
  author={Sarah J Wanner and Victoria E. Prince},
  journal={Development},
  year={2013},
  volume={140 4},
  pages={906-15}
}
Appropriate localization of neurons within the brain is a crucial component of the establishment of neural circuitry. In the zebrafish hindbrain, the facial branchiomotor neurons (FBMNs) undergo a chain-like tangential migration from their birthplace in rhombomere (r) 4 to their final destination in r6/r7. Here, we report that ablation of either the cell body or the trailing axon of the leading FBMN, or 'pioneer' neuron, blocks the migration of follower FBMNs into r5. This demonstrates that the… CONTINUE READING
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Mentioned Connections BETA
AxonNo subtypeNeurons
We find that MLF axons enter r5 only after the pioneer neuron has led several followers into this region ; the MLF is then contacted by projections from the FBMNs .
Here , we report that ablation of either the cell body or the trailing axon of the leading FBMN , or ' pioneer ' neuron , blocks the migration of follower FBMNs into r5 .
This demonstrates that the pioneer neuron and its axon are crucial to the early migration of FBMNs .
Finally , we have found that the adhesion molecule Cdh2 ( N - cadherin ) is important for interactions between the MLF and FBMNs , as well as for interactions between the trailing axon of the pioneer neuron and follower FBMNs .
Axon tracts guide zebrafish facial branchiomotor neuron migration through the hindbrain .
AxonDirect part ofNeurons
We find that MLF axons enter r5 only after the pioneer neuron has led several followers into this region ; the MLF is then contacted by projections from the FBMNs .
Here , we report that ablation of either the cell body or the trailing axon of the leading FBMN , or ' pioneer ' neuron , blocks the migration of follower FBMNs into r5 .
This demonstrates that the pioneer neuron and its axon are crucial to the early migration of FBMNs .
Finally , we have found that the adhesion molecule Cdh2 ( N - cadherin ) is important for interactions between the MLF and FBMNs , as well as for interactions between the trailing axon of the pioneer neuron and follower FBMNs .
Axon tracts guide zebrafish facial branchiomotor neuron migration through the hindbrain .
AxonRegional part ofNeurons
We find that MLF axons enter r5 only after the pioneer neuron has led several followers into this region ; the MLF is then contacted by projections from the FBMNs .
Here , we report that ablation of either the cell body or the trailing axon of the leading FBMN , or ' pioneer ' neuron , blocks the migration of follower FBMNs into r5 .
This demonstrates that the pioneer neuron and its axon are crucial to the early migration of FBMNs .
Finally , we have found that the adhesion molecule Cdh2 ( N - cadherin ) is important for interactions between the MLF and FBMNs , as well as for interactions between the trailing axon of the pioneer neuron and follower FBMNs .
Axon tracts guide zebrafish facial branchiomotor neuron migration through the hindbrain .
AxonAnatomic structure is physical part ofNeurons
We find that MLF axons enter r5 only after the pioneer neuron has led several followers into this region ; the MLF is then contacted by projections from the FBMNs .
Here , we report that ablation of either the cell body or the trailing axon of the leading FBMN , or ' pioneer ' neuron , blocks the migration of follower FBMNs into r5 .
This demonstrates that the pioneer neuron and its axon are crucial to the early migration of FBMNs .
Finally , we have found that the adhesion molecule Cdh2 ( N - cadherin ) is important for interactions between the MLF and FBMNs , as well as for interactions between the trailing axon of the pioneer neuron and follower FBMNs .
Axon tracts guide zebrafish facial branchiomotor neuron migration through the hindbrain .
Finally , we have found that the adhesion molecule Cdh2 ( N - cadherin ) is important for interactions between the MLF and FBMNs , as well as for interactions between the trailing axon of the pioneer neuron and follower FBMNs .
Finally , we have found that the adhesion molecule Cdh2 ( N - cadherin ) is important for interactions between the MLF and FBMNs , as well as for interactions between the trailing axon of the pioneer neuron and follower FBMNs .
Finally , we have found that the adhesion molecule Cdh2 ( N - cadherin ) is important for interactions between the MLF and FBMNs , as well as for interactions between the trailing axon of the pioneer neuron and follower FBMNs .
Finally , we have found that the adhesion molecule Cdh2 ( N - cadherin ) is important for interactions between the MLF and FBMNs , as well as for interactions between the trailing axon of the pioneer neuron and follower FBMNs .
NeuronsNo subtypeAxon
Here , we report that ablation of either the cell body or the trailing axon of the leading FBMN , or ' pioneer ' neuron , blocks the migration of follower FBMNs into r5 .
Axon tracts guide zebrafish facial branchiomotor neuron migration through the hindbrain .
Finally , we have found that the adhesion molecule Cdh2 ( N - cadherin ) is important for interactions between the MLF and FBMNs , as well as for interactions between the trailing axon of the pioneer neuron and follower FBMNs .
We find that MLF axons enter r5 only after the pioneer neuron has led several followers into this region ; the MLF is then contacted by projections from the FBMNs .
This demonstrates that the pioneer neuron and its axon are crucial to the early migration of FBMNs .
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