Axon sprouting in a model of temporal lobe epilepsy creates a predominantly excitatory feedback circuit.

@article{Buckmaster2002AxonSI,
  title={Axon sprouting in a model of temporal lobe epilepsy creates a predominantly excitatory feedback circuit.},
  author={Paul S Buckmaster and Guo Feng Zhang and Ruth Yamawaki},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2002},
  volume={22 15},
  pages={6650-8}
}
The most common type of epilepsy in adults is temporal lobe epilepsy. After epileptogenic injuries, dentate granule cell axons (mossy fibers) sprout and form new synaptic connections. Whether this synaptic reorganization strengthens recurrent inhibitory circuits or forms a novel recurrent excitatory circuit is unresolved. We labeled individual granule cells in vivo, reconstructed sprouted mossy fibers at the EM level, and identified postsynaptic targets with GABA immunocytochemistry in the… CONTINUE READING
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