Axon retraction and degeneration in development and disease.

  title={Axon retraction and degeneration in development and disease.},
  author={Liqun Luo and D D O'leary},
  journal={Annual review of neuroscience},
The selective elimination of axons, dendrites, axon and dendrite branches, and synapses, without loss of the parent neurons, occurs during normal development of the nervous system as well as in response to injury or disease in the adult. The widespread developmental phenomena of exuberant axonal projections and synaptic connections require both small-scale and large-scale axon pruning to generate precise adult connectivity, and they provide a mechanism for neural plasticity in the developing… CONTINUE READING
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