Axon regeneration in the peripheral and central nervous systems.

  title={Axon regeneration in the peripheral and central nervous systems.},
  author={Eric A. Huebner and Stephen M Strittmatter},
  journal={Results and problems in cell differentiation},
Axon regeneration in the mature mammalian central nervous system (CNS) is extremely limited after injury. Consequently, functional deficits persist after spinal cord injury (SCI), traumatic brain injury, stroke, and related conditions that involve axonal disconnection. This situation differs from that in the mammalian peripheral nervous system (PNS), where long-distance axon regeneration and substantial functional recovery can occur in the adult. Both extracellular molecules and the intrinsic… CONTINUE READING
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