Axon position within the corpus callosum determines contralateral cortical projection.

@article{Zhou2013AxonPW,
  title={Axon position within the corpus callosum determines contralateral cortical projection.},
  author={Jing Zhou and Yunqing Wen and Liang She and Ya-nan Sui and Lili Liu and Linda J. Richards and Mu-Ming Poo},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 29},
  pages={E2714-23}
}
How developing axons in the corpus callosum (CC) achieve their homotopic projection to the contralateral cortex remains unclear. We found that axonal position within the CC plays a critical role in this projection. Labeling of nearby callosal axons in mice showed that callosal axons were segregated in an orderly fashion, with those from more medial cerebral cortex located more dorsally and subsequently projecting to more medial contralateral cortical regions. The normal axonal order within the… CONTINUE READING
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