Axon physiology.

  title={Axon physiology.},
  author={Dominique Debanne and Emilie Campanac and Andrzej Bialowas and Edmond Carlier and Gisèle Alcaraz},
  journal={Physiological reviews},
  volume={91 2},
Axons are generally considered as reliable transmission cables in which stable propagation occurs once an action potential is generated. Axon dysfunction occupies a central position in many inherited and acquired neurological disorders that affect both peripheral and central neurons. Recent findings suggest that the functional and computational repertoire of the axon is much richer than traditionally thought. Beyond classical axonal propagation, intrinsic voltage-gated ionic currents together… 

Excitability Tuning of Axons by Afterdepolarization

The mechanisms as well as the functional significance of ADP in fine-scale modulation of axonal spike signaling in the CNS, with special reference to hippocampal mossy fibers, one of the best-studied CNS axons, are focused on.

Activity-dependent mismatch between axo-axonic synapses and the axon initial segment controls neuronal output

Whether the AIS is capable of undergoing structural plasticity in rat hippocampal organotypic slices, which retain the diversity of neuronal cell types present at postnatal ages, is investigated and found that it allows the GABAergic synapses to strongly oppose action potential generation, and thus downregulate pyramidal cell excitability.

The role of axonal Kv1 channels in CA3 pyramidal cell excitability

Kv1 channels located in the axon proper greatly participate in intrinsic excitability of CA3 pyramidal neurons, stressing the importance of the axonal compartment in the regulation of intrinsic neuronal excitability.

Neuronal cultures show bidirectional axonal conduction with antidromic action potentials depolarizing the soma

It is shown that EAPs and antidromic conduction can occur spontaneously, and after distal axotomy or physiological changes in the axon biochemical environment, and have important implications for the study of neuronal function in vitro, reshaping the understanding on how information flows in neuronal cultures.

Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites

Axons are traditionally considered stable transmission cables, but evidence of the regulation of action potential propagation demonstrates that axons may have more important roles. However, their

Modeling analysis of subthreshold voltage signaling along hippocampal mossy fiber axons

  • H. Kamiya
  • Biology
    Frontiers in Cellular Neuroscience
  • 2022
Axons are classically thought of as electrically well isolated from other parts of the neurons due to the shape of a long cable-like structure. In contrast to this classical view on axonal



Information processing in the axon

This review considers recent evidence for the role of intrinsic voltage-gated conductances together with the intrinsic geometrical properties of the axon in the short-term dynamics of neural communication.

Electrogenic Tuning of the Axon Initial Segment

In addition to its main role in AP initiation, the new findings suggest that the AIS is also a site of complex AP modulation by specific types of ion channels localized to this axonal domain.