Axon- or dendrite-predominant outgrowth induced by constituents from Ashwagandha.

  title={Axon- or dendrite-predominant outgrowth induced by constituents from Ashwagandha.},
  author={Tomoharu Kuboyama and Chihiro Tohda and Jing Zhao and Norio Nakamura and Masao Hattori and Katsuko Komatsu},
  volume={13 14},
We previously reported that the methanol extract of Ashwagandha (roots of Dunal) induced dendrite extension in a human neuroblastoma cell line. In this study, we found that six of the 18 compounds isolated from the methanol extract enhanced neurite outgrowth in human neuroblastoma SH-SY5Y cells. Double immunostaining was performed in rat cortical neurons using antibodies to phosphorylated NF-H as an axonal marker, and to MAP2 as a dendritic marker. In withanolide A-treated cells, the length of… CONTINUE READING

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