Axon guidance molecules

  title={Axon guidance molecules},
  author={Roger Keynes and Geoffrey M.W. Cook},
To survey axon guidance in 1995 is to cover a very different field from some 30 years ago, when Sperry elaborated his idea of chemoaffinity to explain the precision of regeneration of the amphibian retinotectal map (Sperry, 1963). With hindsight we know that Sperry was overenthusiastic in his attribution of molecular labels to define tectal addresses and that the role of electrical activity in refining connectivity was yet to be fully appreciated. But at least he could envisage the problem in… CONTINUE READING
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