Axon guidance at the midline: of mice and flies.

  title={Axon guidance at the midline: of mice and flies.},
  author={Timothy A Evans and Greg J Bashaw},
  journal={Current opinion in neurobiology},
  volume={20 1},
In bilaterally symmetric organisms, the midline is a critical organizing center for the developing central nervous system. There is a striking conservation of the molecules and mechanisms that control axon path finding at the midline in vertebrate and invertebrate nervous systems. The majority of axons in the CNS cross the midline before projecting to their contralateral synaptic targets and this crossing decision is under exquisite spatial and temporal regulation. Growing commissural axons… CONTINUE READING