Axon growth is enhanced by NCAM lacking the VASE exon when expressed in either the growth substrate or the growing axon.

@article{Liu1993AxonGI,
  title={Axon growth is enhanced by NCAM lacking the VASE exon when expressed in either the growth substrate or the growing axon.},
  author={Li-dou Liu and Steve Haines and R J Shew and Richard Akeson},
  journal={Journal of neuroscience research},
  year={1993},
  volume={35 3},
  pages={327-45}
}
The neural cell adhesion molecule NCAM exists as several related peptides formed by alternative splicing of the single NCAM gene. Here the ability of NCAM containing and lacking the alternatively spliced VASE exon to act as a permissive growth substrate was tested by examining retinal axon outgrowth on normal L cell fibroblasts and L cells expressing stably transfected 140 kD NCAM +/- VASE. L cells expressing either NCAM form were a more permissive substrate than control L cells. At higher… CONTINUE READING

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